Photo by Amber Palmer

Holiday rentals near Mayo Clinic Florida

We found 1,351 holiday rentals — enter your dates for availability

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July 2025

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Discover a selection of holiday rentals within easy reach of Mayo Clinic Florida that can be your home away from home. Whether you’re travelling with friends, family or just with your pet, holiday homes have the best amenities for hanging out with the people that matter most, which might include parking and a fireplace. No matter what you're looking for, you're sure to find a property to rent that has what everyone needs, including accessible or non-smoking choices.

Holiday rentals with weekly discounts - Mayo Clinic Florida

Showing deals for:3 Oct - 10 Oct

Exceptional

(31 reviews)

TPC Sawgrass Players Club Villa - Ponte Vedra Beach.

Ponte Vedra Beach, FL

8% off

AU$844 per night

includes taxes & fees

Chrome cast TV to stream your favorite shows from your device.

Exceptional

(16 reviews)

4 blocks from beach! spacious getaway w game room, outdoor kitchen. Kid-friendly

Jacksonville Beach, FL

12% off

AU$1,009 per night

includes taxes & fees

Spacious Living Room with Patio off the back and Electric Fireplace

Exceptional

(7 reviews)

Beautiful Townhome 2 Blocks from the beach with beach cruisers!

Jacksonville Beach, FL

8% off

AU$463 per night

includes taxes & fees

Comfortable conversation set under covered pergola with sunshade and bug screen

Exceptional

(62 reviews)

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Jacksonville Beach, FL

11% off

AU$443 per night

includes taxes & fees

Exceptional

(28 reviews)

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Jacksonville Beach, FL

12% off

AU$519 per night

includes taxes & fees

Exceptional

(107 reviews)

Mayo Clinc 1mile from Intercoastal waterfront home w/pool and Breathtaking Views

Jacksonville Beach, FL

9% off

AU$572 per night

includes taxes & fees

Find spaces that suit your style

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Find properties near top attractions in Mayo Clinic Florida

Mayo Clinic Florida

Find the best place to stay - Mayo Clinic Florida

Showing deals for: 1 Oct - 4 Oct

Charming retreat near Downtown and the Hospitals. Short drive to the beach.

Sleeps 6 · 3 bedrooms · 1 bathroom

for 3 nights, 1 home

AU$332 per night

includes taxes & fees

Super Cute & Cozy Home Near Everything With Fenced Back Yard, TV, A C, W/ D

Sleeps 6 · 2 bedrooms · 1 bathroom

for 3 nights, 1 home

AU$21,361 per night

includes taxes & fees

Jax Beach home. Close to the beaches, shops, restaurants and bars.

Sleeps 4 · 2 bedrooms · 1 bathroom

for 3 nights, 1 apartment

AU$270 per night

includes taxes & fees

Top rated rentals - Mayo Clinic Florida

Fantastic ocean views from the living room

Premier Host

Just perfection by the beach

We thoroughly enjoyed ourselves and the Happy pineapple was the perfection location and space. Everything is so well thought out for a perfect family visit. We had our 3 and 6 year old with us and all the beach toys left there for us was so useful and great we didn’t have to spend money on. The hosts were great and so responsive, we couldn’t of asked for better and location was perfect for restaurants too!! Salt lake, lynches and the Thai around corner we’re our favs. Thank you so much, we highly recommend to anyone. Marissa

Marissa P.

Stayed Oct 2019

Peace of mind
Our Book with Confidence Guarantee gives you 24/7 support
More quality time
From booking to staying, the whole process is simple and enjoyable
All the privacy of home
Enjoy full kitchens, laundry, pools, gardens and more
More for less
More space, more privacy, more amenities — more value