Jacksonville_MayoClinicFlorida_6127706_04

Holiday rentals near Mayo Clinic Florida

We found 1,359 holiday rentals — enter your dates for availability

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January 2026

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Discover a selection of holiday rentals within easy reach of Mayo Clinic Florida that can be your home away from home. Whether you’re travelling with friends, family or just with your pet, holiday homes have the best amenities for hanging out with the people that matter most, which might include parking and a fireplace. No matter what you're looking for, you're sure to find a property to rent that has what everyone needs, including accessible or non-smoking choices.

Holiday rentals with weekly discounts - Mayo Clinic Florida

Showing deals for:17 Apr - 24 Apr

Exceptional

(36 reviews)

TPC Sawgrass Players Club Villa - Ponte Vedra Beach.

Ponte Vedra Beach

7% off

for 7 nights, 1 home

AU$538 per night

includes taxes & fees

3rd floor king suite with ocean view balcony

Exceptional

(60 reviews)

Ocean View! 100 steps to feet in the sand! Super Clean!

Jacksonville Beach

8% off

for 7 nights, 1 home

AU$690 per night

includes taxes & fees

Exceptional

(29 reviews)

3-bedroom vacation home 14 minutes from St. Johns Town Center

Ponte Vedra Beach

8% off

for 7 nights, 1 home

AU$595 per night

includes taxes & fees

Exceptional

(40 reviews)

Cozy & Cheerful Oceanfront 2-bedroom condo w/ pool

Jacksonville Beach

8% off

for 7 nights, 1 apartment

AU$581 per night

includes taxes & fees

Wonderful

(33 reviews)

Modern 2BR Condo Steps from Jacksonville Beach

Jacksonville Beach

7% off

for 7 nights, 1 apartment

AU$355 per night

includes taxes & fees

Exceptional

(90 reviews)

Seahorse Cottage Bungalow - Only 7 Blocks from the Beach

Jacksonville Beach

11% off

for 7 nights, 1 home

AU$476 per night

includes taxes & fees

Exceptional

(36 reviews)

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Jacksonville

11% off

for 7 nights, 1 home

AU$418 per night

includes taxes & fees

Exceptional

(29 reviews)

Beach, restaurants, shopping and near Mayo Clinic!

Jacksonville Beach

10% off

for 7 nights, 1 home

AU$550 per night

includes taxes & fees

Exceptional

(86 reviews)

A Few Steps from the Atlantic Ocean Beautiful Beach House Sleeps 8

Jacksonville Beach

8% off

for 7 nights, 1 home

AU$809 per night

includes taxes & fees

Exceptional

(8 reviews)

200 ft to toes in the sand...restaurants, shopping, biking, Mayo Clinic nearby!

Jacksonville Beach

8% off

for 7 nights, 1 home

AU$591 per night

includes taxes & fees

Exceptional

(25 reviews)

Octopi the Beach - Luxury oceanside home 10 min to Mayo and pet friendly

Jacksonville Beach

12% off

for 7 nights, 1 home

AU$611 per night

includes taxes & fees

Exceptional

(10 reviews)

The Palm – Bright & Airy Jacksonville Beach Retreat & 7 mins to Mayo

Jacksonville Beach

8% off

for 7 nights, 1 home

AU$370 per night

includes taxes & fees

The fenced yard is a tropical oasis, perfect for morning coffee.

Exceptional

(18 reviews)

Your Jacksonville Beach Retreat – Fenced Yard, Near Mayo, Walk to Surf & Dining

Jacksonville Beach

8% off

for 7 nights, 1 home

AU$403 per night

includes taxes & fees

Wonderful

(6 reviews)

2 homes for 1 - Arcade, Firepit, Patio - Main house & Lrg guest house included!

Jacksonville

7% off

for 7 nights, 1 home

AU$454 per night

includes taxes & fees

Exceptional

(19 reviews)

Luxury Living at the Blue Pearl great for families or groups.

Jacksonville Beach

8% off

for 7 nights, 1 home

AU$1,107 per night

includes taxes & fees

Exceptional

(42 reviews)

Ocean Breeze. Cozy apartment 2 Blocks from the ocean and within 6 miles of MAYO

Jacksonville Beach

7% off

for 7 nights, 1 apartment

AU$368 per night

includes taxes & fees

Exceptional

(10 reviews)

Location! Location! Location! BEACH, Shopping, Park, All 3 min walk! Super Clean

Jacksonville Beach

8% off

for 7 nights, 1 home

AU$633 per night

includes taxes & fees

Wonderful

(47 reviews)

Oceanside 1st floor home, 1 block away from beach and 15 mins away from Mayo

Jacksonville Beach

11% off

for 7 nights, 1 apartment

AU$337 per night

includes taxes & fees

Excellent

(14 reviews)

Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!

Jacksonville

11% off

for 7 nights, 1 home

AU$347 per night

includes taxes & fees

Exceptional

(58 reviews)

LUXURIOUS Oceanfront - Beachdrifter 201 South-end w wrap around balcony+pets ok*

Jacksonville Beach

8% off

for 7 nights, 1 apartment

AU$683 per night

includes taxes & fees

Find spaces that suit your style

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Find properties near top attractions in Mayo Clinic Florida

Mayo Clinic Florida

Find the best place to stay - Mayo Clinic Florida

Premier Host

Charming 2-bedroom townhome in gorgeous Ponte Vedra Beach

Sleeps 5 · 2 bedrooms · 1+ bathroom

Oceanside 1st floor home, 1 block away from beach and 15 mins away from Mayo

Sleeps 4 · 2 bedrooms · 1 bathroom

Premier Host

Pablo Pointe- Single Family Home directly across from the Mayo Clinic

Sleeps 6 · 3 bedrooms · 2 bathrooms

Top rated rentals - Mayo Clinic Florida

Image of Oceanfront GORGEOUS renovated 2bed 2bath garage, elevator, pool HAS EVERYTHING

Premier Host

Kim’s Place is Wonderful!

Everything promised and more!From covered, secure parking, to easy entry, updated and very comfortable furnishings, beds and beach furniture. The place is spotless, well-organized and very well equipped! Appliances and washer/dryer, coffee maker and accessories are virtually new. Deck offers a great view of the beach (only steps away) and lots of places to eat are within easy walks. The beach is wide, with clean white sand, lifeguards and great swimming. This is a place well visit again and again!

Tim S.

Stayed July 2025

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