La Mesa guest houses
We found 46 guest houses — enter your dates for availability
Explore La Mesa guest house rentals
Luxury Guest-residence in a Beautiful garden just 15min from San Diego & Beaches
Sleeps 4 · 1 bedroom · 1 bathroom
Cottage in the Garden. New! Modern!
Sleeps 4 · 1 bedroom · 1 bathroom
Peaceful Two Bed Oasis | King Bed, Garden, Laundry, Parking
Sleeps 4 · 1 bedroom · 1 bathroom
La Mesa Hillside Studio | Private Patio + Fast Wifi
Sleeps 3 · 1 bedroom · 1 bathroom
Designer Poolside La Mesa Retreat w/ BBQ & Yard
Sleeps 4 · 1 bedroom · 1 bathroom
Charming 2 Room La Mesa Casita w/ Pool, BBQ & Yard
Sleeps 6 · 2 bedrooms · 1 bathroom
Top rated guest house rentals - La Mesa
San Diego Spring
Excellent apartment located smack between Little Italy and the gaslight district.
The apartments are very modern with everything you need. We will be back
Frank
Stayed May 2025
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More quality timeFrom booking to staying, the whole process is simple and enjoyable
All the privacy of homeEnjoy full kitchens, laundry, pools, gardens and more
More for lessMore space, more privacy, more amenities — more value