Top 10% of guest reviews in this areaTop 10% of guest reviews in this area
3 bedrooms1+ bathroomSleeps 5148.6 sq m
Popular amenities
Kitchen
Outdoor space
Parking available
Fireplace
Explore the area
Cape Girardeau, MO
Riverfront Park
Place, Riverfront Park
2 min walk
Riverfront Bridge Park
Place, Riverfront Bridge Park
5 min walk
Century Casino & Hotel Cape Girardeau
Place, Century Casino & Hotel Cape Girardeau
19 min walk
Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
Airport, Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
9 min drive
Rooms & beds
3 bedrooms (sleeps 5)
Back bedroom
1 Double Bed
Master bedroom
1 King Bed
Middle bedroom
2 Single Beds
1 bathroom, 1 half bathroom
Main floor bathroom
Toilet
Upstairs Bathroom
Bathtub or shower · Toilet
Spaces
Deck or patio
Porch or lanai
Kitchen
Balcony
Separate dining area
Outdoor play area
Garden
About this property
Serenity South -- Gardens, River-Views, and Refreshing Space
Beautifully renovated duplex with large shared yard in Cape Girardeau Historic District. Cozy living room, large dining room, fully stocked kitchen, 3 second-story bedrooms with balcony at the end of the hall, and 1 1/2 bathes. Perfect for getting away for rejuvenation or exploring downtown. Within walking distance to local downtown restaurants, antique shops, and boutiques. Two blocks from the Mississippi River and many other attractions.
Add dates for prices
Amenities
Kitchen
Air conditioning
Outdoor space
Parking available
Fireplace
Have a question?
AI iconBetaBeta
Get instant answers with AI powered search of property information and reviews.
Similar properties
Charming Home Retreat Among Majestic Trees - Near SEMO, Capaha Park & Downtown
Cape Girardeau
Charming Home Retreat Among Majestic Trees - Near SEMO, Capaha Park & Downtown
Events allowed: family gatherings, birthday parties, weddings
Parties or events must okayed before arrival.
default
Pets
No pets allowed
default
Smoking
Smoking is not permitted
Back yard is shared with the other side of the duplex. Please respect their use of the common space.
Important information
You need to know
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
Parties and events (including family gatherings, birthday parties and weddings) are allowed on site. Maximum attendees: 50
Note from host: Parties or events must okayed before arrival.
Host has indicated that there is a carbon monoxide detector on the property
Host has indicated that there is a smoke detector on the property
Safety features at this property include a deadlock
About the area
Cape Girardeau
Located in Cape Girardeau, this holiday home is near a water park and on a river. The area's natural beauty can be seen at Shawnee National Forest and Mississippi River. Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center are also worth visiting. Discover the area's water adventures with power boating and fishing nearby, or enjoy the great outdoors with horse riding and cycling.
Century Casino & Hotel Cape Girardeau - 19 min walk - 1.6 km
Southeast Missouri State University - 2 min drive - 1.8 km
Getting around
Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 12 min drive
Restaurants
Sand's Pancake House - 11 min walk
Greens Garden Urban Market + Kitchen - 5 min walk
Katy O'Ferrell's Publick House - 9 min walk
Roni’s Mac Bar - 16 min walk
Minglewood Brewery - 7 min walk
Frequently asked questions
Is Serenity South -- Gardens, River-Views, and Refreshing Space pet-friendly?
No, pets are not allowed at this property.
How much does it cost to stay at Serenity South -- Gardens, River-Views, and Refreshing Space?
As of 16 Apr 2026, prices found for a 1-night stay for 2 adults at Serenity South -- Gardens, River-Views, and Refreshing Space on 7 June 2026 start from AU$189, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.
How much is parking at Serenity South -- Gardens, River-Views, and Refreshing Space?
On-site parking is available at the property.
What time is check-in at Serenity South -- Gardens, River-Views, and Refreshing Space?
Check-in begins at 4:00 PM.
What time is check-out at Serenity South -- Gardens, River-Views, and Refreshing Space?
Checkout is at 11:00 AM.
Where is Serenity South -- Gardens, River-Views, and Refreshing Space located?
Situated on a river, this holiday home is steps away from eDen Spa & Salon, Shawnee National Forest and Mississippi River. Riverfront Park and The Glenn House are also within 5 minutes.
Reviews
10
Exceptional
Reviews are presented in chronological order, subject to a moderation process, and verified unless otherwise labelled.
This is a beautiful, well-maintained historic home in a neat part of town -- walking distance to lots of attractions. The hospitality was off the charts. Every detail was thought out. Bed was comfortable, AC worked great, and wonderful spaces (dining room, living room, porch) to hang out in!
Charming house within walking distance to downtown restaurants and bars. Host is wonderful! Great communication.
Deborah K.
Stayed 1 night in Sep 2025
Verified
10/10 Excellent
John
10 Dec 2023
Liked: Cleanliness, property conditions & facilities, communication
Great place.
John
Stayed 1 night in Dec 2023
Verified
8/10 Good
Michael W.
10 Nov 2025
Liked: Cleanliness, check-in, communication
All was good except for the strange fact of 3 rentals at the same place and the older couple in the backyard was a little off putting.
Michael W.
Stayed 1 night in Oct 2025
Response from VrboOwner on 11 Nov 2025
I am sorry for the surprised of a shared backyard space. It is clearly stated multiple times on our listing that it is a duplex that has shared backyard space. And yes, one of the neighbors is a quiet older couple. This is located in a densely populated downtown area. As per the message sent immediately after booking …if you misunderstood the nature of the space, you were welcome to cancel for a full refund. My offer was declined. I am sorry it wasn’t as expected.
The property was exactly as listed with so many little touches that made it special. Communication was great and we were close to downtown shops and the casino. We will definitely stay again when we are in the area.
We loved staying at this house for SEMO family weekend! It was super clean and had everything we needed and more 😊 we will definitely try to stay here again!
Moving our daughter in to the dorm at SEMO for yr 2. Been coming to this location since our trip here during her senior year of HS when she visited SEMO to audition for the musical theatre program. It is a great place to stay when you have more than 2 people.
Three generations found rest,beauty,& joy at Serenity South. Thoughtful touches,beautiful gardens and Cape charm made this more than a stay-it became a treasured memory. We were so appreciative of the details, the fresh flowers, homemade cookies, the coffeemaker upstairs and the books and games. The beds were all comfortable. We enjoyed this historical home and our stay.
When looking for a VRBO for our daughter's college visit, we knew the perfect place to stay! This is our second stay at Serenity South and it was just as incredible as the first visit. Clean, inviting and cozy. Thanks Jo for another beautiful stay.